628 research outputs found
Cognitive decline in the elderly : epidemiologic studies on cognitive function and dementia
In the last decades, the awareness has grown among the public, as well as among
health politicians, that dementia is highly prevalent in older age, that it causes much
distress to patients and their families, and that it poses a large burden on public health
care resources.Initially, research focused chiefly on Alzheimer's disease, the most
frequent type of dementia. In recent years, there is also increasing interest in vascular
dementia. The reasons for this are that vascular dementia may be more prevalent
than previously recognized, that vascular causes may be involved in the clinical picture
of other dementia syndromes as well, and, perhaps most importantly, that vascular
causes of cognitive decline can potentially be influenced by available measures of
intervention.
In studies of the frequency and etiology of dementia, much emphasis has been
put on differentiating demented subjects from cognitively unimpaired individuals.
However, there is little evidence to support the idea of a sharp distinction between
demented and non-demented persons. Cognitive impairment is a quantitative rather
than a qualitative characteristic, and consequently its distribution in the population
shows a continuum of severity. The fact that cognitive dysfunction is common in
old age does not imply that it is intrinsic to aging; it may be normal in the sense of
usual, not in the sense of natural
This thesis focuses on epidemiologic studies on cognitive function and dementia.
The main part is devoted to investigations of the relation between vascular risk factors
and cognitive function; in these studies cognitive function was evaluated as a
continuously distributed variable. In the other studies in this thesis, risk factors for
dementia were investigated with dementia as a dichotomous outcome variable
A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly
The objective of this study was to investigate the longitudinal relation
between the insulin-like growth factor I (IGF-I)/IGF-binding protein
(IGFBP) system and cognitive function. The study population consisted of a
sample of 186 healthy participants from the population-based Rotterdam
Study, aged 55-80 yr. At baseline, we determined fasting blood levels of
free and total IGF-I, IGFBP-1, and IGFBP-3. The 30-point Mini-Mental State
Examination (MMSE) was used to assess cognitive impairment at baseline
(MMSE score of <26; 6% of the sample) and cognitive decline after, on the
average, 1.9 yr of follow-up (drop in MMSE score of >1 point/year; 22% of
the sample). Odds ratios (OR) and 95% confidence intervals (95% CI) were
estimated using logistic regression, with adjustment for age, sex,
education, body mass index, and fasting insulin levels. Total IGF-I
appeared to be inversely related to cognitive impairment, although not
significantly. Higher total IGF-I and the total IGF-I/IGFBP-3 ratio were
associated with less cognitive decline (OR per SD increase = 0.65; 95% CI
= 0.44-0.95 and OR = 0.59; 95% CI = 0.39-0.87, respectively). No relation
was observed between free IGF-I and cognitive decline (OR = 0.99; 95% CI =
0.68-1.44). In conclusion, in this prospective study higher serum total
IGF-I levels and higher total IGF-I/IGFBP-3 ratios, but not higher free
IGF-I levels, were associated with less cognitive decline over the
following 2 yr. Circulating total IGF-I levels may reflect an underlying
biological process that influences cognitive decline
Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008
Stroke incidence rates have decreased in developed countries over the past 40 years, but trends vary across populations. We investigated whether age-and-sexspecific stroke incidence rates and associated risk factors as well as preventive medication use have changed in Rotterdam in the Netherlands during the last two decades. The study was part of the Rotterdam Study, a large populationbased cohort study among elderly people. Participants were 10,994 men and women aged 55-94 years who were stroke-free at baseline. Trends were calculated by comparing the 1990 subcohort (n = 7516; baseline 1990-1993) with the 2000 subcohort (n = 2883; baseline 2000-2001). Poisson regression was used to calculate incidence rates and incidence rate ratios in age-and-sex-specific strata. We further compared the prevalence of stroke risk factors and preventive medication use in the two subcohorts. In the 1990 subcohort 467 strokes occurred during 45,428 person years; in the 2000 subcohort 115 strokes occurred in 18,356 person years. Comparing the subcohorts, incidence rates decreased by 34% in men, but remained unchanged in women. Blood pressure levels increased between 1990 and 2000, whereas the proportion of current cigarette smokers decreased in men, but not in women. There was a strong increase in medication use for treatment of stroke risk factors across all age categories in both sexes. Our findings suggest that in Rotterdam between 1990 and 2008 stroke incidence rates have decreased in men but not in women
Socioeconomic differences in stroke among Dutch elderly women: the Rotterdam Study
BACKGROUND AND PURPOSE: We sought to assess the association between
socioeconomic status and the risk of stroke among elderly women.
Methods--The association between socioeconomic status and stroke emerged
in cross-sectional and longitudinal data on 4274 female participants of
the Rotterdam Study, a prospective, population-based, follow-up study in
the Netherlands among older subjects. RESULTS: A history of stroke was
more common among women in lower socioeconomic strata. The same trend was
observed for the relationship between the lowest socioeconomic groups and
the incidence of stroke. Risk factors for stroke were not related to
socioeconomic status in a consistent manner. Smoking, history of
cardiovascular diseases, and overweight were more common in lower
socioeconomic groups. However, socioeconomic differences in hypertension,
antihypertensive drug use, prevalence of atrial fibrillation, and
prevalence of left ventricular hypertrophy were not observed. The complex
of established risk factors could only partly explain the association
between socioeconomic status and stroke. CONCLUSIONS: There is a strong
association among elderly women between socioeconomic status and stroke.
The association could only partly be explained by known risk factors. Our
findings indicate that not only the actual risk profile but also risk
factors earlier in life may be of importance
Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy
Purpose: Adjuvant chemotherapy for breast cancer can have adverse effects on cognition shortly after administration. Whether chemotherapy has any long-term effects on cognition is largely unknown, yet it becomes increasingly relevant because of the widespread use of chemotherapy for early-stage breast cancer and the improved survival. We investigated whether cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy for breast cancer is associated with worse cognitive performance more than 20 years after treatment. Patients and Methods: This case-cohort study compared the cognitive performance of patients with breast cancer who had a history of adjuvant CMF chemotherapy treatment (six cycles; average time since treatment, 21 years; n = 196) to that of a population-based sample of women never diagnosed with cancer (n = 1,509). Participants were between 50 and 80 years of age. Exclusion criteria were ever use of adjuvant endocrine therapy, secondary malignancy, recurrence, and/or metastasis. Results: The women exposed to chemotherapy performed significantly worse than the reference group on cognitive tests of immediate (P = .015) and delayed verbal memory (P = .002), processing speed (P < .001), executive functioning (P = .013), and psychomotor speed (P = .001). They experienced fewer symptoms of depression (P < .001), yet had significantly more memory complaints on two of three measures that could not be explained by cognitive test performance. Conclusion: Survivors of breast cancer treated with adjuvant CMF chemotherapy more than 20 years ago perform worse, on average, than random population controls on neuropsychological tests. The pattern of cognitive problems is largely similar to that observed in patients shortly after cessation of chemotherapy. This study suggests that cognitive deficits following breast cancer diagnosis and subsequent CMF chemotherapy can be long lasting
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